Ameliorating effects of cinnamon and curcumin on oxidative stress in lithium-pilocarpine induced status epilepticus model

The lithium-pilocarpine (Li-Pc) model of status epilepticus (SE) is most convenient and frequently used for pathophysiological management strategies in search new, safe effective therapeutic agents including the natural remedies SE. Oral administration cinnamon (CIN) curcumin (CUR) can reduce neuroinflammation which a common feature neurodegenerative disorders. Although many studies on CUR effects SE has been undertaken, to our best knowledge no study conducted studying effect CIN present explores neuroprotective food products Li-Pc induced rats. was experimental rats using lithium – pilocarpine model. Besides control groups, animals were also grouped as treatment groups received pre-treatment before induction severity seizures, cognitive dysfunctions, oxidative stress parameters estimated forebrain tissue all group animals. Treatment with significantly ameliorated frequency epileptic seizures dose-dependent manner. dysfunctions well indices (enzymatic non-enzymatic) dosedependently by order CUR<CIN parameters. Possible application antiepileptic antioxidant great potential warrants further